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The 16th Pharmacovigilance Report on Covid-19 vaccines also updates information on possible menstrual disorders.
Although it is less present in everyday life, covid is still active and its treatment continues to be a source of unknowns that health organizations try to analyze in depth. The latest Pharmacovigilance report on vaccines against covid-19 published by the Spanish Agency for Medicines and Health Products (AEMPS) records 75.978 notifications of adverse events in the 102.480.101 doses of vaccines that have been administered in Spain until July 10, which correspond to a total of 41.243.255 people who have received at least one dose (65% from Pfizer, 23% from Moderna, 10% from AstraZeneca and 2% from Janssen).
Furthermore, the omicron subvariants BA.4 and BA.5 accounted for 75,5% of covid cases during the week of July 11 to 17, according to the 'Update on the epidemiological situation of SARS-CoV-2 variants in Spain' report, published last Tuesday by the Ministry of Health. Extremadura is in the lead, with 98,8%, in the presence of BA.4 and BA.5. Behind them are the Basque Country (98,4%) and Cantabria (97,9%), with Aragón in tenth place (93,2%). Getting vaccinated remains the best option to prevent infection or mitigate it in these new highly contagious variants.
However, Side effects of vaccines continue to be detected and there is no shortage of references to those less used today. Among the most frequently reported are fever and pain in the vaccination area, nervous system (headache and dizziness) and the musculoskeletal system (myalgia and arthralgia). Nevertheless, The dossier reveals that extensive inflammation in the vaccinated limb has been identified as a possible adverse reaction in the Moderna vaccine (Spikevax). Of course, this disorder does not require treatment and resolves spontaneously in a few days.
Pfizer Side Effects
In Spain, 66.653.390 doses of Comirnaty (Pfizer) have been administered, corresponding to 28.811.334 people, as of July 10. During this period there have been registered a total of 40.708 reports of adverse events (74% in women and 83% in people between 18 and 65 years old). 7.579 were considered serious. The ten most reported side effects are:
- Pyrexia 13.040 cases, 32%
- Headache 8.662 cases, 21%
- Myalgia 6.237 cases, 15%
- Pain in the vaccination area 5.288 cases, 13%
- Discomfort 4.778 cases, 12%
- Fatigue 3.054 cases, 8%
- Lymphadenopathy 2.827 cases, 7%
- Nausea 2.588 cases, 6%
- Chills 2.339 cases, 6%
- Asthenia 2.290 cases, 6%
On the other hand, until July 10, 2022, of the 40.708 notifications registered after the Comirnaty administration, 421 correspond to children. Until that date, more than 3.2 million doses were administered in Spain, so the notification rate is estimated at 13 notifications registered per 100.000 doses administered. The ten most reported side effects in children are:
- Pyrexia 80 cases, 19%
- Lymphadenopathy 71 cases, 17%
- Headache 58 cases, 13%
- Pain in the vaccination area 35 cases, 8%
- Vomiting 29 cases, 7%
- Discomfort 27 cases, 6%
- Diarrhea 21 cases, 5%
- Urticaria 20 cases, 5%
- Eruption 15 cases, 4%
- Fatigue 15 cases, 4%
- Abdominal pain 13 cases, 3%
- Dizziness 12 cases, 3%
Moderna Side Effects
As of July 10, 2022, a total of 24.053.326 doses of this vaccine (5.342.870 people) have been administered in Spain. In this period, a total of 16.856 reports of adverse events after administration of the Spikevax vaccine (72%) in women) and 2.285 were considered serious.
The ten most reported adverse events with Moderna are:
- Pyrexia 7.316 cases, 43%
- Headache 3.810 cases, 23%
- Myalgia 2.965 cases, 18%
- Pain in the vaccination area 2.461 cases, 15%
- Discomfort 2.348 cases, 14%
- Fatigue 1.283 cases, 8%
- Chills 1.241 cases, 7%
- Nausea 1.188 cases, 7%
- Lymphadenopathy 994 cases, 6%
- Arthralgia 917 cases, 5%
Source: Heraldo de Aragón
