Title

UNLOOC: Unlocking data content of Organ-On-Chips - GA: 101140192


Description

Before drugs can proceed to clinical trials on human subjects, animal models have traditionally been used to validate the effectiveness, toxicity and pharmacokinetics of the drug. However, use of animal models comes with many potential challenges, such as lower predictability to humans, high failure rates in clinical trials, excessive costs in drug development and risk of death caused by unwanted side effects in approved drugs.

UNLOOC aims to develop groundbreaking Organ-on-Chips (OOC) technologies to mitigate the challenges posed by use of animals in drug development and testing. Direct use of human cells is a real game changer, bridging the gender gap and allowing personalized medicine.


Objectives and Results

The UNLOOC project tackles the challenge inherent in animal testing of drugs, aiming to demonstrate through its five novel use cases how the groundbreaking methods using Organ-on-a-Chip (OOC) technology enable the development of more effective treatments, leaving animal subjects out of the equation. The OOC technology to be developed in the UNLOOC project will not only enable controlled drug testing, but also the modeling of disease pathophysiology.

Use case 1: Developing human OOC diversity panels and demonstrating the impact on the drug efficacy and safety testing using advanced multi-parametric AI-based analysis.

Use case 2a: Standardized Single-Organ Smart OOC Multi-well Plate (SOMP) evaluated with epithelium-on-chip and cancer-on-chip.

Use case 2b: Multi-Organ Smart OOC Multi-well Plate (MOMP) with integrated sensors for the prediction of oral drug absorption.

Use case 3: Skin-on-Chip for Pharma Applications and Chemical Compound Testing.

Use case 4: Integrated fluidic control, sensing, and incubation system for the BBB-on-Chip

Use case 5: Lung-on-Chip.


IP IIS Aragon

Ignacio OCHOA GARRIDO


Financing Agency

The project Unlocking data content of Organ-On-Chips (UNLOOC), file code 101140192, of the call HORIZON-KDT-JU-2023-1-IA of the European Union Framework Programme for Research (Horizon Europe) and the Call for International Collaboration Projects of the State Research Agency, is funded by:

Europe: This project is supported by the Chips Joint Undertaking and its members Belgium, Germany, Hungary, Ireland, Italy, the Netherlands, Portugal, Romania, Spain, Switzerland. This work includes top-up funding from the Swiss State Secretariat for Education, Research and Innovation (SERI).

Spain: Project PCI2024-153529 funded by MICIU/AEI/10.13039/501100011033 and Co-financed by the European Union


Coordinator

Microfluidic ChipShop GmbH


Be a partner

51 partners from 10 different European countries


Duration

01/05/2024 – 30/04/2027