Early diagnosis of this disease is key to facilitating access to treatments aimed at controlling and managing symptoms. However, this is not always possible. The advance of this team of researchers from the USA could improve the accuracy of its detection.
Experts at the Langone Health academic medical center, located in New York (USA), have made a promising discovery about the Alzheimer's that could change the way diagnose this diseaseThe study, published in the journal Molecular Psychiatry, shows how two molecules in the blood can reveal its progress more accurately. The researchers were able to identify the severity of Alzheimer's with 93% accuracy.
The new Alzheimer's detection method would allow monitoring with just a blood test. / Fickr
Currently, more than 800 Spaniards suffer from this pathology, most of them over 000 years old and predominantly women. This study could be a crucial step towards understanding why they are more vulnerable.
Changes in two molecules
The scientists discovered that the levels of two molecules in the body They change differently in men and women as Alzheimer's progresses: acetyl-L-carnitine and free carnitine. In women, both gradually decrease as the disease worsens, while in men only one of them shows changes.
Research opens the door to a future much simpler diagnosisCurrently, detecting this pathology requires invasive procedures such as lumbar punctures. The new method would allow monitoring with just a blood test.
93% accuracy
Researchers were able to identify the severity of Alzheimer's disease with 93% accuracy by combining these new biomarkers with traditional methods.
Currently, more than 800 Spaniards suffer from this pathology, the majority over 000 years of age and predominantly women.
“Our findings provide the strongest evidence yet for identifying those with Alzheimer's,” he said. Betty Bigio, lead researcher on the study. The research could not only improve diagnosis, but also open new avenues for future treatments.
Reference: Bigio, B., Lima-Filho, RAS, Barnhill, O. et al. 'Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer's disease in two independent study cohorts'. Mol Psychiatry (2025).
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