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The research, published in the magazine 'Cancers', has been carried out by scientists from the Cardiovascular Diseases area of the CIBER (CIBERCV), of the Barcelona Biomedical Research Institute (IIBB-CSIC).
A team of researchers has discovered that accumulating low-density lipoproteins (LDL) in the extracellular matrix provides a source of cholesterol that contributes to the growth and proliferation of tumor cells in pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer.
The research, published in the magazine 'Cancers', has been carried out by scientists from the Cardiovascular Diseases area of the CIBER (CIBERCV), from the Barcelona Biomedical Research Institute (IIBB-CSIC), from the Sant Pau Biomedical Research Institute (IIB Sant Pau) and from the Hospital del Mar Medical Research Institute (IMIM).
PDAC is one of the biggest challenges in the field of oncology, with a five-year survival rate of no more than 9%, being the third cause of cancer-related death in developed countries.
These LDL have a high probability of being trapped and modified (aggregated) in the extracellular matrix, becoming a source of cholesterol for tumor cells.
"Our hypothesis is that aggregated LDL They provide a relatively inexhaustible source of cholesterol for PDAC cells and are a contributing factor to their growth and proliferation."summarized Vicenta Llorente, researcher at CIBERCV, IIB Sant Pau and IIBB-CSIC, and one of the coordinators of this study.
The researchers focused on the mechanisms that measured the effect of added LDL on the intracellular relationship of cholesterol and the growth of pancreatic tumor cells and then considered the effectiveness of peptides designed to inhibit LDL aggregation in these processes, as a potential antitumor therapeutic strategy.
Following the results, the researchers have proposed that anti-LDL aggregation peptides "deserve further investigation as antitumor strategies in this type of cancer", given that "could contribute to limiting the proliferation of cancer cells in very early stages of disease".
Source: Heraldo de Aragón
