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20 December, 2024The researcher from the IIS Aragón and the University of Zaragoza talks in this interview about his work leading the Group 'Molecular bases of atherosclerosis. Mediterranean diet and atherosclerosis'' (GIIS009), and what is your daily life like?
Jesús de la Osada García, PhD in Pharmacy and Professor of Biochemistry and Molecular Biology, has been 37 years in the world of research. Always with a great vocation, the researcher combined his work as a resident pharmacist with the completion of his doctoral thesis. In addition, his experience at Tufts University in Boston and at Chapel Hill University in North Carolina gave him very important notions to complete his research training and to be able to work with pioneering researchers and even Nobel Prize winners.
Currently he combines his work as a teacher in Medicine, Veterinary Medicine and Biotechnology at the University of Zaragoza with his research facet leading the group associated with the IIS Aragón and reference group of the Government of Aragón “Mediterranean diet and its nutraceutical potential”. Jesús de la Osada has been conducting research at the IIS Aragón since its founding.
What lines of research are being worked on in your group?
In my group we mainly work on four lines:
- Study of the effects of squalene on lipid droplets and lipoprotein metabolism in vivo in various animal models.
- Analysis of the effect of new nanoparticles with squalene on cell lines and in vivo.
- Investigation of squalene metabolites in cholesterol biosynthesis in cell lines.
- Searching for the role of squalene-induced droplet proteins using high-fidelity CRISPR-cas9.
What is the main challenge your research group is currently facing?
Our main challenge is to know the mechanisms of action of squalene both in vivo , the vitro.
Any ongoing projects that you would like to highlight?
I would like to highlight the project “PID2022-136414OB-I00” funded by the State Research Agency. A project to support our main challenge: to understand the molecular mechanisms of squalene action in vivo e vitro.
What profiles make up your research team?
My team is interdisciplinary: veterinarians, biologists, biotechnologists, chemists, pharmacists and food science and technology.

Why should companies bet on research, and specifically, on your group?
To develop new formulations of the squalene and enriched virgin olive oilsThese are the fields in which we collaborate with companies.
Advice for someone starting out in healthcare research?
Enjoy your work day after day and do it with the highest quality possible.