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11 February, 2020A group of researchers has examined the benefits and risks of nonsteroidal anti-inflammatory drugs.
Researchers at Florida Atlantic University (United States) have conducted a study in which they have examined the benefits and risks of non-steroidal anti-inflammatory drugs (NSAIDs) with and without prescription for pain relief, such as 'Aspirin', ibuprofen, naproxen , diclofenac ('Voltaren') or paracetamol.
All of these medications have benefits and risks. 'Aspirin' reduces inflammation as well as coronary events and strokes, but increases gastrointestinal symptoms and bleeding, however, without adverse liver or kidney consequences, as the researchers explain.
For their part, they indicate that NSAIDs without 'Aspirin' decrease inflammation, but have been associated with significant adverse coronary events and strokes with long-term use, as well as significant side effects in the upper stomach and kidney. , and electrolyte imbalances such as high sodium or potassium content and even heart failure.
Acetaminophen has no clinically relevant anti-inflammatory properties and is responsible for more than 50 percent of drug overdoses related to liver failure and about 20 percent of liver transplant cases, as well as kidney diseases, according to scientists explain.
"With respect to the benefits and risks of analgesics, the totality of evidence suggests that physicians and their patients should make individual clinical judgments based on the patient's entire risk factor profile. Making individual clinical decisions about prescribing of NSAIDs to relieve pain based on all these considerations has the potential to do much more good than harm," explains Manas Rane, one of the main authors of this work, which has been published in the Journal of Cardiovascular Pharmacology and Therapeutics. '.